Bioadhesive Microspheres for Bioavailability Enhancement.

Mucoadhesive microspheres are one of the important novel drug delivery systems which can cause localization of the drug at site of absorption. Bioadhesion is a phenomenon in which two materials at least one of which is biological and are held together by means of interfacial forces.

The mucoadhesive properties of chitosan and chitosan microspheres were evaluated by studying the interaction between mucin and chitosan in aqueous solution by turbidimetric measurements and the measurement of mucin adsorbed on the microspheres. A strong interaction between chitosan microspheres and mucin was detected.

Objective: The present work is to formulate the mucoadhesive microspheres loaded Paracetamol using two different natural gums with an aim to increase the GI retention time, enhance bioavailability over prolonged period of time in the stomach and.

The prepared microspheres exhibited good mucoadhesive properties as observed in in vitro wash-off test when compared to a non-mucoadhesive polymer, ethyl cellulose microspheres. The drug release mechanism was non-fickian type controlled by swelling and relaxation of polymer chain.

Results: The formulated mucoadhesive microspheres were discrete, free flowing and SEM studies indicated that the Maraviroc microspheres were almost spherical in shape. The prepared mucoadhesive microsphere formulations having entrapment efficiency of 66.66%- 89.78% and mucoadhesion of 02-37% at the end of 8 hours.

The mucoadhesive microspheres of HPG were prepared by water in oil solvent evaporation technique. Preliminary trials were carried out to optimize the process of preparation. Batches HM-1 to HM-16 were prepared to study the effect of drug to polymer ratio, emulsifier concentration, temperature and agitation speed on the % drug entrapment efficiency and particle size.

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In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug.

To plan different cross-linked alginate mucoadhesive microspheres for controlled release of medication, utilization of mucoadhesive polymer mix with sodium alginate was one of the generally acknowledged methodologies. Blending of sodium alginate with any suitable polymer can enhanced the encapsulation efficiency and stability of drug (6,7).

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Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies.